SentroProbe DR MS7 NIR

Multispot probe for highly increased sample volume

Overview

The SentroProbe MS7 is a multispot process probe designed to take measurements across a chute filled with moving powder in diffuse reflectance mode.

It is commonly paired with the GEA Consigma Light House assembly and used to analyze powder in the slow-moving zones between the outlet of the final blender in a GEA CDC line and the tablet press. When combined with a SentroPAT FO with an internal 9W NIR source, the SentroProbe MS7 can provide vital process information about a continuous manufacturing process.

Seven measurements spots assess large masses of across a moving powder stream
Drift correction of NIR source in connected SentroPAT FO provides outstanding long term stability
Combatible with GEA Consigma Light House assembly, including wash-in-place (WIP) skid, providing in-line probe cleaning and referencing capability
GMP-friendly design

Applications

Combined with a SentroPAT FO system, the SentroProbe MS7 is a powerful tool for monitoring several different types of oral solid dose unit operations. The ability to clean the probe in place when combined with the GEA Consigma light house assembly makes the SentroProbe MS7 an attractive option for dry blends that have a tendency to stick to probe surfaces.

Wet Granulation

The SentroProbe MS7 can be used to assess granule API potency and moisture levels after granule drying and milling and prior to addition to final blend.

Dry granulation

The SentroProbe MS7 can be used to assess granule API potency after granule milling and prior to addition to final blend.

Final Blend Potency

The SentroProbe MS7 can be used to assess final blend API potency immediately prior to tableting. This potency estimate can be used as an input for BU and CU assessment, which may be used as part of a real-time release (RTR) strategy in continuous manufacturing.

Technical Specifications

Optics

Dimensions, Materials of construction

Measurement type	Diffuse Reflectance
Measurement distance	Direct contact with sample material
Spot Size	7 spots each with ca. 5mm
Signal variation between spots	<15% RSD
Fiber cable setup	7 x 24 x 200 μm fibers for illumination 7 x 200 μm separate detection fibers or merged with a fiber taper to 1 x 400 μm FSMA 905 terminated Illumination fiber bundles with a 6 mm ferrule type connector
Fiber cable length and design	Y-shaped cable with a total length of 3 m. Extension up to 5.5 m in 0.5 m steps. Split section approx. 500 mm

Probe materials	Stainless Steel 1.4404 – Sapphire – Stainless Steel 1.4404 Rounded shape
Surface quality of 1.4404	Ra < 0.4 μm
Probe diameter	12mm
Sapphire tube length	60mm
Total shaft length	477mm
Sealing	Use of sealing rings or glue compliant with FDA requirements
Fiber cable protection	Stainless steel tube with silicone made overcoat to ease cleaning

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Frequent Asked Questions

Learn more about the SentroProbe DR MS7 NIR and its wide range of applications in pharmaceutical manufacturing. This section provides additional insights and detailed information to help you fully understand the potential and versatility of our cutting-edge sensor technology.

How long can the fiber optic cable of the SentroProbe MS7 be manufactured?

The maximum stock is 5.5m.

When would someone use a SentroProbe MS7 rather than a SentroProbe DR LS?

It depends! Both probes can be used to assess critical quality attributes of blends during processing, but differ in how their interface to a process. The different probes would also require different process simulators if a process simulator is desired for method development. It is hard to give a detailed analysis without more information, but in general: both probes can be used successfully for many applications, with the limiting factor often being how the probe is integrated into the process. For example, it would be very hard to put a SentroProbe DR MS7 into a tablet press or a SentroProbe DR LS into a GEA LightHouse Probe assembly.

This probe is intended for product contact and has a sapphire window. Is sapphire an allowed material for product contact in a GMP environment?

We have many installations in GMP commercial manufacturing that use a SentroProbe MS7 in product contact. Suffice to say, yes, this has been accepted by regulators. To that end, we provide material certificates with each SentroProbe MS7.

What can I use to clean a SentroProbe MS7?

We generally recommend 70% isopropanol. However, if you’d prefer to use a different cleaning solution, please contact your local Sentronic representative to discuss compatibility with our probes.

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