SentroPAT DA

Non-invasive monitoring of bin blending processes

Learn More About SentroPAT DA

Overview

The SentroPAT DA is a compact NIR analyzer for non-invasive, online monitoring of pharmaceutical powder bin blending. It provides valuable insights and controls blend time, optimizing production efficiency. Compatible with various blenders, this system features a high-performance InGaAs diode array spectrometer for accurate spectral resolution, long-term stability, and superior system-to-system comparability.

 

The system allows real-time monitoring of blend uniformity and quantitative analysis of APIs using chemometric models, eliminating the need for traditional lab sampling. Its user-friendly design includes simple mounting, minimal maintenance, and easy cleaning for GMP compliance.

 

Data integrity is maintained through embedded buffering and seamless integration with plant IT systems, ensuring secure, real-time data transmission. The SentroPAT DA enhances blending control, reduces costs, and supports consistent product quality.

 

 

Applications

Explore the possibilities the SentroPAT DA offers for the monitoring and end point detection of your bin blending process.

Qualitative Analysis
A variety of options for qualitative BU monitoring is available for the SentroPAT DA.
Quantitative analysis
Comprehensive interfaces to established chemometrics software allow a execution of quantitative models in real-time.
Coming soon: Iterative Optimization Technology
Based on IOT (Iterative Optimization Technology) quantitative analysis will be possible without a need of cost and time consuming calibrations.
  • High-performance InGaAs diode array spectrometer
  • Extended spectral range for full CH-region covering
  • Compact and lightweight design
  • Non-invasive, contactless measurement
  • WiFi transmission
  • Seamless integration into PAT management systems
  • User-friendly mounting and GMP-compliant surfaces
  • Built-in accelerometer for measurement triggering
  • No need for lamp replacement
  • Compliance with USP<1856> and EP 2.2.40 standards

Technical Data

SentroPAT DA
Software Interfaces
Mounting Options
Spectrometer Type Diode Array (512 pixel InGaAs linear array)
Spectral Range 1100 - 1900nm
Spectral Resolution approx. 10nm FWHM
Wavelength accuracy +/- 1 nm over full spectral range
Wavelength reproducibility < 0.2nm
Internal reference Internal wavelength and intensity reference
Photometric linearity Fulfilling USP<1856> and EP 2.2.40 requirements
Data acquisition time < 1s (configurable, typically 0.5 - 1s)
Sampling interface Non contact, through sapphire window
Measurement spotsize approx. 10mm diameter
Measurement trigger software controlled by 3 axis accelerometer, synchronized to blender rotation
Power supply replaceable Li-Ion battery, > 6hrs operation External power supply (24 VDC) for lab operation and recharging
Enclosure IP65 / NEMA4, cGMP conform, Aluminum anodized
Dimensions 170 x 105 x 60 mm (W x D x H) Height: add 36 mm for flange
Weight 2.2 kgs including battery
Communications WiFi (802.11 a/g/n)
Operation Conditions 10° - 30°C; 10% - 90% relative humidity
Software SentroSuite GMP on external PC
Validation Software integrated validation routines according USP<1856>, EP2.2.40
Mounting 4" or 2" sanitary flange, additional options available
Chemometric Interfaces SIMCA, VektorDirektor
OPC-UA on external PC
OPC-DA based on dedicated remote server
Integrated to PAT management systems SIPAT, synTQ, ProaXesS
SDK A software developer kit is available to directly develop interfaces using TCP/IP protocol
Flange kit Flange kit for welding into IBCs or lids including sapphire window
Adapters Variety of adapter for mounting on larger flanges or existing ports
Download data sheet

Need personal assistance? We’re here to help!

Looking for more tailored support? Don’t hesitate to reach out—we’re happy to assist you! Or explore our knowledge base for in-depth insights and technical details.

Mounting options

Several mounting options are available to enable the use of the system with different scale and types of blenders. Contact us, if you need help with you specific integration requirements!

2" flange
The 2" flange is the native version without additional adapters and suitable for small lab scale up to production scale blenders.
4" flange
Compatible to all SentroPAT BU flange connections and NIR types. The conversion between 2" and 4" is easy and user friendly.
6" flange
This flange option was developed for compatibility with legacy NIR bin blending solutions.

Frequent Asked Questions

Find answers to common questions about the SentroPAT DA and its applications in pharmaceutical manufacturing.

Will spectra be lost if the system loses its Wi-Fi connection during a blending run?

The SentroPAT DA stores the 600 most recently collected spectra in a buffer, which will be sent to the External PC once Wi-Fi communication is established. It is very rare that a single blend lasts 600 revolutions or more, so the liklihood of losing data during blending due to loss of Wi-Fi is very, very low.

Do the NIR light sources need to be changed routinely?

No, the sources are intended to last the lifetime of the instrument. A second, redundant source has been added to the system and can be switched to via a software parameter change if an NIR source stops functioning, avoiding unnecessary service downtime.

Will the SentroPAT DA fit on my V-blender?

It's hard to give a definite answer here without knowing specifics of the blender, it's associated enclosure, and how the SentroPAT DA will be mounted to the blender. Many customers have successfully integrated a SentroPAT DA on their small scale blenders, including V-blenders. If you have questions about your system, please reach out!

How do I recharge the SentroPAT DA?

There are two ways to power the system. When connected to a power supply, the system automatically recharges its internal Li-Ion battery. Additionally, the battery can be easily swapped for a fully charged one. An external charger, which is included, allows charging additional batteries while the system remains in use. This is particularly useful for long operating periods without sufficient downtime for recharging. 

 

In some cases, customers ensure continuous power supply by using slip rings on the blender.

Contact

Are you interested in purchasing the SentroPAT DA or have any questions regarding it? Our sales representative will be happy to help you.

Have questions? I'm here to help—reach out today!
Sebastian Sowinski
Key Account Manager Sentronic GmbH
Have questions? I'm here to help—reach out today!
Owen Rehrauer
President Sentronic US Corp.

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